ea0041gp51 | Cardiovascular endocrinology | ECE2016
Wolf Peter
, Winhofer Yvonne
, Smajis Sabina
, Jankovic Drazenka
, Anderwald Christian-Heinz
, Trattnig Siegfried
, Luger Anton
, Krebs Michael
, Krssak Martin
Background: Obesity is a major risk factor to develop heart failure, in part due to possible lipotoxic effects of increased intramyocardial (MYCL) and/or pericardial (PERI) lipid accumulation. Recent evidence suggests that MYCL is highly dynamic and might rather be a surrogate marker for disturbed energy metabolism than the underlying cause of cardiac dysfunction. On the other hand, PERI might contribute directly by mechanic and paracrine effects. Therefore, we hypothesized th...